Frontal cortex functional activity modulation impact on the stereotypic, emotional and postural behavior in rats during the interictal period of pilocarpine-induced chronic epileptogenesis

The cholinergic mechanisms role determination in epileptogenesis attracts the attention of researchers. Pilocarpine administration rats contributes to chronic form epileptiform activity development characterized by presence a pronounced acute stage and an interictal period - free from behavioral convulsive reactions. We consider most important feature pilocarpine-induced seizures might be change various forms nonconvulsive behavior. Attempts investigate animals’ reactions details during seizure-free period, as well determine similar types behavior formation, are interesting. purpose work is motor, stereotypic aggressive-defensive throughout syndrome with frontal cortex functional change. It was found that severity non-convulsive mostly determined state. At same time, hyperactivation epileptogenesis. authors proved when activated rats, there increase horizontal vertical motor activity, expressiveness emotional “open field” test strengthening In conditions this part selective destruction opposite effects noted which confirms formation. Observed modulation, according authors, indicate reasonability regulatory influences searching aiming forward brain activate complex aimed elimination.